20 Best American Strains of Marijuana: Seed Guide

20 Best American Weed Strains List Top

America’s best cannabis genetics: 20 top-rated US marijuana strains ready to grow from seeds! Discover premium US weed strains with this ultimate buyers’ guide and secure authentic American cannabis seeds with fast local shipping.

The best American strains of cannabis are highly in-demand. Marijuana breeders in the US have earned a reputation for producing sought-after weed strains with incredible strength and supreme quality.

You can grow American genetics as a beginner or professional by buying US marijuana seeds online.

Every American strain listed below is ready to purchase in feminized or autoflower seeds.


Best Feminized American Strains

OG Kush

OG Kush American weed strain

OG Kush is the most popular American weed strain to date. This highly potent and flavorful US-grown marijuana has dominated the cannabis markets since the 1990s. Although OG Kush plants are challenging to cultivate, both indoor and outdoor growers find them rewarding. Its distinctive buds are large, chunky, and rich in trichomes, accompanied by a sour, woody scent. With a THC content reaching 26%, OG Kush offers a strong and quick-acting effect.

Flowering Time 8–10 weeks
Brand Humboldt Seed Co.
Pack Size 5 seeds
Yield High

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Runtz

Runtz marijuana US strain seeds

Runtz is an award-winning American marijuana strain, named for its colorful, candy-like buds. A hybrid of Zkittlez and Gelato, it yields potent, exotic weed with high resin content. Runtz grows quickly, maturing in 55–60 days after flowering, and remains compact in both indoor and outdoor cultivation. With THC levels between 25–29%, it delivers a strong and long-lasting effect. Its buds shine in trichomes, emitting a sweet ‘n’ fruity aroma with a hint of sour citrus. Boasting high yields and top-shelf buds, Runtz is a favorite among cultivators and users alike.

Flowering Time 55–60 days
Brand Barney’s Farm
Pack Size 1/3/5/10 seeds
Yield Up to 600 g/m2

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Grand Daddy Purple

Grand Daddy Purple aka GDP marijuana strain

Grand Daddy Purple, also known as GDP, ranks as one of the finest purple weed strains originating from the USA. This Northern California indica is a blend of Purple Urkle, a renowned West Coast strain celebrated for its striking purple buds, and Big Bud, known for its robust yield. The hybridization results in GDP producing ample purple-colored buds of exceptional quality with powerfully sedative effects. GDP feminized seeds are easy to cultivate and thrive in a variety of climates, boasting a THC content of up to 23%.

Flowering Time 8 weeks
Brand Ken’s GDP
Pack Size 5 seeds
Yield 450–500 g/m2

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Blue Dream

Blue Dream weed strain West Coast USA

Blue Dream is a remarkable sativa strain originating from Humboldt County that’s loved by commercial growers and aficionados alike. This strain exhibits massive growth potential and yields impressively large harvests from cannabis plants the size of trees. The buds are sizeable, crystal-covered, and emit a sweet blueberry aroma. Blue Dream’s effects bring on an uplifting and mentally invigorating experience, containing high levels of THC and terpenes.

Flowering Time 9–10 weeks
Brand Seedsman
Pack Size 1–100 seeds
Yield 500 g/m2

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Wedding Cake

Wedding Cake strain USA fem seeds

Wedding Cake, a potent indica-dominant strain from the US, is named for its sweet vanilla cake aroma. This strain perfectly balances cerebral euphoria with physical relaxation. Growing Wedding Cake marijuana plants is straightforward, making it suitable for growers of all skill levels. The plants yield generously and produce dense buds, caked in resin and featuring pink or purple highlights. With a 25% THC content, Wedding Cake promises a rich, indulgent experience.

Flowering Time 9–10 weeks
Brand ILGM
Pack Size 5/10/20 seeds
Yield 18–21 oz/3x3ft

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Strawberry Cough

Strawberry Cough American weed strain seeds

Strawberry Cough is a well-known American marijuana strain, renowned for its distinctively fruity aroma and flavor, reminiscent of ripe strawberries. This award-winning sativa hybrid is highly favored for its exceptional taste among cannabis enthusiasts. The feminized seeds of Strawberry Cough grow into robust, bushy plants that are easy to cultivate, offering average yields of above-average weed. Its effects promote clarity and energy, with a THC content of up to 25%.

Flowering Time 10–11 weeks
Brand Homegrown
Pack Size 4/8/12/24 seeds
Yield 14 oz/m2

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MAC

MAC strain weed seeds USA

MAC, which stands for Miracle Alien Cookies, is an indica-leaning hybrid with extraordinarily dense and resinous buds. This American strain of marijuana is a best-seller in dispensaries across the nation. MAC feminized seeds grow into short plants with large yields. MAC weed is liberally coated in trichomes with a sweet smell and flavor like sour cherry yogurt. With 23–27% THC, its effects are very powerful and promote feelings of well-being and clear-headed euphoria.

Flowering Time 8–9 weeks
Brand Blimburn
Pack Size 1–100 seeds
Yield 600 g/m2

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Gelato

Gelato weed strain American genetics

Gelato, also known as Larry Bird, is a popular West Coast cookies strain of weed famous for its ice-cream shop aroma. It’s a blend of Sunset Sherbet and Thin Mints GSC, offering a sweet and earthy terpene profile. Highly potent, Gelato has a THC content of 25–27%, providing a relaxing and euphoric experience. This all-American strain yields well both indoors and outdoors and has a quick flowering time of 65–70 days. Gelato, a balanced mix of 40% sativa and 60% indica, is a sought-after choice for its enjoyable effects and abundant harvest.

Flowering Time 65–70 days
Brand Barney’s Farm
Pack Size 1/3/5/10 seeds
Yield Up to 650 g/m2

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Green Crack

Green Crack USA weed seeds

Green Crack, also known as Cush, is an American sativa-dominant strain that’s named for its highly energizing effects. This popular strain features sweet and skunky flowers, covered in shimmering trichomes. Ideal for novice growers, Green Crack feminized seeds offer vigorous growth, natural resilience, and heavy yields in various climates. The buds hit hard with up to 22% THC.

Flowering Time 10 weeks
Brand ILGM
Pack Size 5/10/20 seeds
Yield 18–21 oz/3x3ft

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Bubba Kush

Bubba Kush American cannabis genetics

Bubba Kush is a potent indica strain originating from the US that gained popularity along the West Coast. Prized for its powerfully narcotic effects, Bubba Kush is an ideal choice for medical cannabis users. The buds are dense and resin-rich, exhibiting hash-like aromas and flavors. Characterized by a stout growth, Bubba Kush plants feature broad leaves and tightly clustered flowers, with THC levels ranging from 16–24%.

Flowering Time 9 weeks
Brand Seedsman
Pack Size 1–100 seeds
Yield 500 g/m2

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Do-Si-Dos

Do-Si-Dos Cannabis Strain US

Do-Si-Dos, also known as Dosi Doe or Dosi, is an in-demand American indica hybrid, a blend of OG Kush Breath and Face Off OG. This strain boasts impressive bag appeal and potent effects, with THC levels nearing 30%. It exudes a strong, sweet, and earthy aroma, accompanied by equally delightful flavors. The stone is predominantly physical, delivering a potent body high. Cultivating Do-Si-Dos feminized seeds is simple, as the plants maintain a compact size and don’t demand expert care.

Flowering Time 8–10 weeks
Brand Blimburn
Pack Size 1–100 seeds
Yield 400–500 g/m2

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Purple Haze

Purple Haze cannabis strain US breeder seeds

Purple Haze, an old-school sativa strain from the Emerald Triangle, gained widespread popularity through the Jimi Hendrix song bearing its name. This classic weed is renowned for its trippy, psychoactive effects that stimulate creativity, averaging around 18% THC. Its purple buds are loaded with trichomes, backed by a sweet and exotic terpene profile. The plant flourishes outdoors and also performs exceptionally well indoors.

Flowering Time 8–10 weeks
Brand Homegrown
Pack Size 4/8/12/24 seeds
Yield 21 oz/m2

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NYC Diesel

NYC Diesel Marijuana Strain Seeds

NYC Diesel, a marijuana strain named aptly after its East Coast origins, features chunky flowers that reek of diesel fuel. This legendary American weed strain delivers a long-lasting high, balancing cerebral euphoria with a powerful body stone. Feminized seeds of NYC Diesel develop into robust female plants, yielding abundant harvests for those who cultivate this sativa-dominant cultivar patiently. It contains around 20% THC.

Flowering Time 9–11 weeks
Brand ILGM
Pack Size 5/10/20 seeds
Yield 14–17 oz/plant

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Best Autoflower American Strains

Zkittlez Auto

Zkittlez Autoflowering Seeds USA

Zkittlez Auto, an autoflowering version of the renowned American cannabis strain Zkittlez, stands out as one of the sweetest-tasting autoflower strains available. These feminized seeds develop into relatively short plants, characterized by robust vigor and high yield, reaching maturity in just 90 days from seed. The final product boasts a supreme potency, with THC levels ranging from 21–24%.

Flowering Time 90 days
Brand Seedsman
Pack Size 1–100 seeds
Yield 400–500 g/m2

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Girl Scout Cookies Auto

Girl Scout Cookies Autoflower Fem Seeds USA

Girl Scout Cookies Auto is an autoflowering variant of the renowned Girl Scout Cookies marijuana strain, originating from the San Francisco Bay Area. This strain is celebrated globally for its exceptional quality. The feminized seeds of Girl Scout Cookies Auto produce compact female plants, yielding buds that are both potent and resin-rich, complete with the distinctive cookie scent and taste, complimented by a hefty 20% THC content.

Flowering Time 9–10 weeks
Brand Fast Buds
Pack Size 1–100 seeds
Yield 450–600 g/m2

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Trainwreck Auto

Trainwreck Auto West Coast USA Marijuana Strain

Trainwreck Auto is an autoflower plant bred from the acclaimed NorCal strain Trainwreck. This low-maintenance weed strain is perfect for beginners and outdoor growers due to its small size, high yields, and mold resistance. Trainwreck Auto has a life cycle of 10–13 weeks. When fully mature, its lime green buds are dense and sticky with resin. The effect is nearly tranquilizing and can be a source of great relief to medical cannabis users.

Flowering Time 75–90 days
Brand Humboldt Seed Co.
Pack Size 10 seeds
Yield High

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Purple Kush Auto

Purple Kush Autoflower American Weed Seeds

Purple Kush Auto is an autoflowering version of one of the best Kush strains in America, Purple Kush. Purple Kush Auto buds have a beautiful purple color and thick resin coating that’s sure to impress any indica lover. Its calming effects allow for a deep sense of relaxation. Purple Kush Auto seeds become plants with a bushy indica structure and grow only 1–2 feet tall. Average 18% THC.

Flowering Time 10 weeks
Brand Homegrown
Pack Size 4/8/12/24 seeds
Yield 12–14 oz/m2

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Bruce Banner Auto

Bruce Banner strain autoflower seeds American

Bruce Banner Auto is an autoflower version of the mighty Bruce Banner strain from Colorado. These massive buds are sticky, delicious, and unusually potent. Bruce Banner Auto seeds grow shorter, bushier, and faster than the original strain, making it generally easier for beginners and to those who want a quicker harvest with a small footprint. Up to 25% THC.

Flowering Time 10–11 weeks
Brand Fast Buds
Pack Size 1–100 seeds
Yield 450–600 g/m2

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Gorilla Glue #4 Auto

Gorilla Glue #4 Autoflower Cannabis Seeds USA

Gorilla Glue #4 Auto is an autoflowering take on the award-winning US strain Gorilla Glue, named for its gluey resin. Gorilla Glue marijuana has a pungent sour fragrance and provides strong euphoric yet relaxing effects. Gorilla Glue #4 Auto performs well grown indoors or outdoors and produces high yields of dank weed, boasting effective THC levels of 18–24%.

Flowering Time 8–9 weeks
Brand Blimburn
Pack Size 1–100 seeds
Yield 400–600 g/m2

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Sour Diesel Auto

Sour Diesel Autoflower Humboldt Seeds America

Sour Diesel Auto is a autoflower version of the iconic American weed strain Sour Diesel. Its has the classic sour gas aroma and flavor that Cali tokers know and love. Sour Diesel Auto seeds take between 75–85 days from seed to harvest. The plants are easy to grow and have a fair resistance to cannabis mold despite the density of its buds. The effects of Sour Diesel Auto promote energy and mental stimulation.

Flowering Time 75–85 days
Brand Humboldt Seed Co.
Pack Size 5/10 seeds
Yield High

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Jared Cox profile image

Jared Cox is the author behind Mold Resistant Strains. He is a cannabis grower, breeder, and archivist of seeds. His work across several disciplines extensively covers cannabis genetics, cultivation, processing, and sales.

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